Estrogen treatments may sharpen mental performance in women with certain medical conditions, but University of Florida researchers suggest that recharging a naturally occurring estrogen receptor in the brain may also clear cognitive cobwebs (see also Cancer Gene Therapy).
The discovery suggests that drugs can be developed to offset "senior moments" related to low estrogen levels, as well as to protect against neurological diseases, all while avoiding the problems associated with adding estrogen to the body.
Writing online in Molecular Therapy in July, scientists with UF's McKnight Brain Institute describe how they improved thought processes in female mice bred with the inability to produce estrogen receptor-alpha, a protein apparently necessary for healthy learning and memory.
"We were able to restore function in these animals, not by dosing them …
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